2025 (32 citations)

 

2025 Featured Modelling late gastrulation in stem cell-derived monkey embryo models. Nature. 649,161–172

 

2025 Featured A Complete Model of Mouse Embryogenesis Through Organogenesis Enabled by Chemically Induced Embryo Founder Cells. Cell. 188,21

 

A brain-to-small intestine circuit mediates morphine-induced constipation in male mice. Nature Communications. doi:10.1038/s41467-025-67765-7

 

Descendants of hypertrophic chondrocytes promote angiogenesis by secreting THBS4 during bone growth and injury repair. Bone Research. 13,92

 

A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling. Nature Biomedical Engineering. doi:10.1038/s41551-025-01538-x

 

Spatiotemporal Delivery of Required Facilitators for Microenvironment Remodeling Propels Neural Regeneration after Spinal Cord Injury. Advanced Materials. doi:10.1002/adma.202503479

 

The FN1-targeted Delivery of Low-molecular-weight heparin to Venous Clots Revolutionizes Thrombosis Treatment in CVT. Biomaterials. 326,123653

 

Periaortic lymphatic vessels protect against thoracic aortic dissection through mobilizing immune response. Cardiovascular Research. 121,16

 

A quantitative analysis of TAAR1-positive cells in whole mouse brain by FDISCO technology. Neuroscience. 584,286

 

Targeting ligand PDL1 for cardiotoxicity assessment and cardiac protection in immune-related myocarditis. Nanomedicine. 21,2

 

Chemical dehydration-induced ultrafast clearing method for human tissues. View. doi:10.1002/VIW.20250104

 

Rapid sonication-assisted whole tissue clearing and immunostaining. Sci. Rep. 35101

 

Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps. Cancer Cell. 43,9

 

Gastrula-Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross-Talk with TGF-𝜷 Signaling Pathway. Advanced Science. doi:10.1002/advs.202500895

 

Electroacupuncture-Medication Combined Therapy Improves Sepsis Outcomes by Regulating PVN Neuronal Activities. Current Medical Science. 45,1513–1528

 

LNPs-mediated VEGF-C mRNA Delivery Promotes Heart Repair and Attenuates Inflammation by Stimulating Lymphangiogenesis Post-myocardial Infarction. Biomaterials. 322,123410

 

Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in stroke. eBioMedicine. 112,105568

 

Anti-angiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules. Hepatology. doi: 10.1097/HEP.0000000000001426

 

Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF. Circulation. 155, 23 

 

Hypoxia-Driven Neurovascular Impairment Underlies Structural-Functional Dissociation in Diabetic Sudomotor Dysfunction. MedComm. doi: 10.1002/mco2.70173 

 

Comprehensive evaluation and application of tissue clearing techniques for 3D visualization of splenic neural and immune architecture. Am J Physiol Cell Physiol. doi.org/10.1152/ajpcell.00084.2025

 

SST neurons in the periaqueductal gray regulate urination and bladder function. Commun. Biol. 8, 639

 

Chemogenetic ablation and regeneration of arterial valve in zebrafish. Biochem. Biophys. Res. Commun. 762, 151786

 

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice. Nat. Commun. 16, 2839

 

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions. Nat. Commun. 16, 3410

 

Life cycle exposure to differentially charged polystyrene nanoplastics leads to gender-specific particle accumulation and neurotoxicity in zebrafish (Danio rerio). Environment International 198, 109441

 

3D visualization of neurovascular networks in pulp-exposed rat molars using tissue clearing techniques. Odontology doi.org/10.1007/s10266-025-01092-7

 

S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning. Mol. Psychiatry doi.org/10.1038/s41380-025-02949-7

 

Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics. Nat. Commun. 16, 2368

 

BOOST: a robust ten-fold expansion method on hour-scale. Nat. Commun. 16, 2107

 

Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection. Sci. Adv. 11, 4

 

PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner. Cell Death & Disease 16, 19

 

 

2024 (15 citations)

 

2024 Featured The interhemispheric amygdala-accumbens circuit encodes negative valence in mice. Science 386, 6722

 

Advanced Nanoplatform Mediated by CRISPR-Cas9 and Aggregation-Induced Emission Photosensitizers to Boost Cancer Theranostics. ACS Nano 18, 48

 

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells. Nat. Commun. 15, 9337

 

Three-dimensional characteristics of T cells and vasculature in the development of mouse esophageal cancer. iScience. doi.org/ 10.1016/j.isci.2024.111380

 

SOLID: minimizing tissue distortion for brain-wide profiling of diverse architectures. Nat. Commun. 15, 8303

 

Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury. PNAS 121 (39). doi.org/10.1073/pnas.2404395121

 

Alveolar regeneration by airway secretory-cell-derived p63+ progenitors. Cell Stem Cell. doi.org/10.1016/j.stem.2024.08.005

 

Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays. Sci. Adv. 10, 27 doi.org/10.1126/sciadv.ado9120

 

Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution. Nat. Ecol. Evol. doi.org/10.1038/s41559-024-02510-9

 

In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals. Acta Pharmacol. Sin. doi.org/10.1038/s41401-024-01308-6

 

Nerve Regeneration Potential of Antioxidant-Modified Black Phosphorus Quantum Dots in Peripheral Nerve Injury. ACS Nano. doi.org/10.1021/acsnano.4c07285

 

Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles. Nat. Commun. 15, 3987

 

Engineering Large-Scale Self-Mineralizing Bone Organoids with Bone Matrix-Inspired Hydroxyapatite Hybrid Bioinks. Adv. Mater. 2309875

 

Clay Sculpture-Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific-Shaped Tissue Vascularization and Regeneration. Adv. Sci. 2308381

 

A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks. iScience. doi.org/ 10.1016/j.isci.2024.109730

 

 

2023

 

2023 Featured Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization. Nature 624, 630–638

 

Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis. Nat. Commun. 14, 7102

 

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nat. Commun. 14, 5675

 

Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system. Sci Adv. 9(27):eadg2252.

 

Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. Cell Reorts, 42(4):112351

 

A versatile vessel casting method for fine mapping of vascular networks using a hydrogel-based lipophilic dye solution. Cell Reports, 3(2):100407

 

Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development, The EMBO Journal, 42:e111364

 

Photostimulation of lymphatic clearance of β-amyloid from mouse brain: a new strategy for the therapy of Alzheimer’s disease. Front. Optoelectron. 16(45)

 

Tissue optical clearing imaging for structural changes of neuromuscular junctions after mice ischemic stroke. Chinese Optics Letters. 21(12):120061

 

 

2022

 

Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury, Cell Discov. 8, 118

 

Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush. Neural Regen. Res., 18(4), 913-921.

 

Copper stress impairs angiogenesis and lymphangiogenesis during zebrafish embryogenesis by down-regulating pERK1/2 foxm1-MMP2/9 axis and epigenetically regulating ccbe1 expression. Angiogenesis, 25, 241–257.

 

 

2021

 

Fluorescent Carbon Dots Shuttling between Mitochondria and the Nucleolus for in Situ Visualization of Cell Viability. ACS Appl. Bio. Mater., 4, 928-934.

 

H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus interspecies infection in humans. PLoS Pathog. 17(12), E1010098.

 

CUBIC-plus: An optimized method for rapid tissue clearing and decolorization. Biochem. Biophys. Res. Commun., 568, 116-123.

 

Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis. PLoS Biol., 19(8), e3001357.

 

 

2020

 

Dual beam-shear differential interference microscopy for full-field surface deformation gradient characterization. J. Mech. Phys. Solids., 145, 104162.

 

 

2019

 

Visualization of protein sorting at the trans-Golgi network and endosomes through super-resolution imaging. Front. Cell Dev. Biol., 7, 181.

 

Light sheets with extended length. Opt. Commun., 450, 166-171.

 

RIM and RIM-BP form presynaptic active-zone-like condensates via phase separation. Mol. Cell, 73(5), 971-984.

 

Quantitative surface topography of martensitic microstructure by differential interference contrast microscopy. J. Mech. Phys. Solids, 124, 102-114.

 

 

2018

 

TEFM enhances transcription elongation by modifying mtRNAP pausing dynamics. Biophysical Journal, 115(12), 2295-2300.

 

Development of in planta chemical cross-linking-based quantitative interactomics in arabidopsis. J. Proteome Res., 17(9), 3195-3213.

 

Impairment of inhibitory synapse formation and motor behavior in mice lacking the NL2 binding partner LHFPL4/GARLH4. Cell Reports, 23(6), 1691-1705.

 

An integrated single- and two-photon non-diffracting light-sheet microscope. Rev. Sci. Instrum., 89(4), 043701.

 

ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations. Proc. Natl. Acad. Sci. USA, 115(2), E292-E301.

 

 

2017

 

GAS2L1 is a centriole-associated protein required for centrosome dynamics and disjunction. Developmental Cell, 40(1), 81-94. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development. Proc. Natl. Acad. Sci. USA, 114(33), E6992-E7001.

 

 

2016

 

Visualizing Plant Cells in A Brand New Way. Molecular Plant, 9(5), 633-635.

 

ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity. J. Neurophysiol, 116, 201-209.

 

A distinct pathway for polar exocytosis in plant Cell wall formation1. Plant Physiology, 172, 1003-1018.

 

Multicolor 4D fluorescence microscopy using ultrathin Bessel light sheets. Sci. Rep., 6, 1-6.