2025

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Comprehensive evaluation and application of tissue clearing techniques for 3D visualization of splenic neural and immune architecture.  Am J Physiol Cell Physiol. doi.org/10.1152/ajpcell.00084.2025

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SST neurons in the periaqueductal gray regulate urination and bladder function. Commun. Biol. 8, 639

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Chemogenetic ablation and regeneration of arterial valve in zebrafish. Biochem. Biophys. Res. Commun. 762, 151786

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Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice. Nat. Commun. 16, 2839

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Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions. Nat. Commun. 16, 3410

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Life cycle exposure to differentially charged polystyrene nanoplastics leads to gender-specific particle accumulation and neurotoxicity in zebrafish (Danio rerio). Environment International 198, 109441

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3D visualization of neurovascular networks in pulp-exposed rat molars using tissue clearing techniques. Odontology doi.org/10.1007/s10266-025-01092-7

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​S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning. Mol. Psychiatry doi.org/10.1038/s41380-025-02949-7​

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Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics. Nat. Commun. 16, 2368

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BOOST: a robust ten-fold expansion method on hour-scale. Nat. Commun. 16, 2107

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Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection. Sci. Adv. 11, 4

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PKCα regulates the secretion of PDL1-carrying small extracellular vesicles in a p53-dependent manner. Cell Death & Disease 16, 19

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2024

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2024 Featured The interhemispheric amygdala-accumbens circuit encodes negative valence in mice. Science 386, 6722

 

​Advanced Nanoplatform Mediated by CRISPR-Cas9 and Aggregation-Induced Emission Photosensitizers to Boost Cancer Theranostics. ACS Nano 18, 48

 

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells. Nat. Commun. 15, 9337

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Three-dimensional characteristics of T cells and vasculature in the development of mouse esophageal cancer. iScience. doi.org/ 10.1016/j.isci.2024.111380

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SOLID: minimizing tissue distortion for brain-wide profiling of diverse architectures. Nat. Commun. 15, 8303

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Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury. PNAS 121 (39). doi.org/10.1073/pnas.2404395121

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Alveolar regeneration by airway secretory-cell-derived p63+ progenitors. Cell Stem Cell. doi.org/10.1016/j.stem.2024.08.005

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Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays. Sci. Adv. 10, 27 doi.org/10.1126/sciadv.ado9120

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Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution. Nat. Ecol. Evol. doi.org/10.1038/s41559-024-02510-9

 

In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals. Acta Pharmacol. Sin. doi.org/10.1038/s41401-024-01308-6

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Nerve Regeneration Potential of Antioxidant-Modified Black Phosphorus Quantum Dots in Peripheral Nerve Injury. ACS Nano. doi.org/10.1021/acsnano.4c07285

 

Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles. Nat. Commun. 15, 3987

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Engineering Large-Scale Self-Mineralizing Bone Organoids with Bone Matrix-Inspired Hydroxyapatite Hybrid Bioinks. Adv. Mater. 2309875

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Clay Sculpture-Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific-Shaped Tissue Vascularization and Regeneration. Adv. Sci. 2308381

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A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks. iScience. doi.org/ 10.1016/j.isci.2024.109730

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2023

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2023 Featured Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization. Nature 624, 630–638

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Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis. Nat. Commun. 14, 7102

 

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nat. Commun. 14, 5675

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Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system. Sci Adv. 9(27):eadg2252.

 

Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. Cell Reorts, 42(4):112351

 

A versatile vessel casting method for fine mapping of vascular networks using a hydrogel-based lipophilic dye solution. Cell Reports, 3(2):100407

 

Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development, The EMBO Journal, 42:e111364

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Photostimulation of lymphatic clearance of β-amyloid from mouse brain: a new strategy for the therapy of Alzheimer’s disease. Front. Optoelectron. 16(45)

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Tissue optical clearing imaging for structural changes of neuromuscular junctions after mice ischemic stroke. Chinese Optics Letters. 21(12):120061

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2022

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Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury, Cell Discov. 8, 118

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Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush. Neural Regen. Res., 18(4), 913-921.

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Copper stress impairs angiogenesis and lymphangiogenesis during zebrafish embryogenesis by down‑regulating pERK1/2‑foxm1‑MMP2/9 axis and epigenetically regulating ccbe1 expression. Angiogenesis, 25, 241–257.

 

2021

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Fluorescent Carbon Dots Shuttling between Mitochondria and the Nucleolus for in Situ Visualization of Cell Viability. ACS Appl. Bio. Mater., 4, 928−934.

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H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus interspecies infection in humans. PLoS Pathog. 17(12), E1010098.

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CUBIC-plus: An optimized method for rapid tissue clearing and decolorization. Biochem. Biophys. Res. Commun., 568, 116-123.

 

Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis. PLoS Biol., 19(8), e3001357.

 

2020

 

Dual beam-shear differential interference microscopy for full-field surface deformation gradient characterization. J. Mech. Phys. Solids., 145, 104162.

 

2019

 

Visualization of protein sorting at the trans-Golgi network and endosomes through super-resolution imaging. Front. Cell Dev. Biol., 7, 181.

 

Light sheets with extended length. Opt. Commun., 450, 166-171.

 

RIM and RIM-BP form presynaptic active-zone-like condensates via phase separation. Mol. Cell, 73(5), 971-984.

 

Quantitative surface topography of martensitic microstructure by differential interference contrast microscopy. J. Mech. Phys. Solids, 124, 102-114.

 

2018

 

TEFM enhances transcription elongation by modifying mtRNAP pausing dynamics. Biophysical Journal, 115(12), 2295-2300.

 

Development of in planta chemical cross-linking-based quantitative interactomics in arabidopsis. J. Proteome Res., 17(9), 3195-3213.

 

Impairment of inhibitory synapse formation and motor behavior in mice lacking the NL2 binding partner LHFPL4/GARLH4. Cell Reports, 23(6), 1691-1705.

 

An integrated single- and two-photon non-diffracting light-sheet microscope. Rev. Sci. Instrum., 89(4), 043701.

 

ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations. Proc. Natl. Acad. Sci. USA, 115(2), E292-E301.

 

2017

 

GAS2L1 is a centriole-associated protein required for centrosome dynamics and disjunction. Developmental Cell, 40(1), 81-94.

Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development. Proc. Natl. Acad. Sci. USA, 114(33), E6992-E7001.

 

2016

 

Visualizing Plant Cells in A Brand New Way. Molecular Plant, 9(5), 633-635.

 

ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity. J. Neurophysiol, 116, 201-209.

 

A distinct pathway for polar exocytosis in plant Cell wall formation1. Plant Physiology, 172, 1003-1018.

 

Multicolor 4D fluorescence microscopy using ultrathin Bessel light sheets. Sci. Rep., 6, 1-6.